Effect of captopril and other inhibitors of angiotensin-converting enzyme on plasma prolidase activity.

of fructosamine values between these two populations are not significantly different. These results imply two different distributions for measurements of Hb A1 but the same gaussian (anamorphosis) distribution for measurements of fructosamine. H,qerglycemk patients. Statistical analysis of the data (Mann-Whitney test) shows a significant difference of fructosamine averages between normal subjects and those with impaired glucose tolerance (IGT) (2) or diabetic patients with hemoglobinopathies (P <0.01 each); the significance of the difference is weaker for Hb A1 data (respectively, nonsignificant and P <0.05). As expected, fructosamine assay more efficiently detects undiagnosed diabetes in patients with hemoglobinopathies and seems to have good potential to be used as a screening test in populations in which hemoglobinopathies are common. The assay does not require subjects to be fasting, is easily automated, and is low cost.